Find the gaps in evidence synthesis
Describe a clinical area. SynthGap searches 33 million PubMed articles, checks each candidate against 500,000+ systematic reviews, and proposes novel meta-analysis topics — with the primary studies to back them.
Search the literature
We retrieve the studies closest to your topic from a 33-million-article PubMed index.
Check what's covered
Each candidate is cross-checked against 500,000+ systematic reviews to find where synthesis is missing or outdated.
Get novel topics
Receive specific, justified topics with a PICO framework and the primary studies each would include.
Every topic comes with its evidence
Not just a suggestion — the framework, the studies, and the reasoning behind it.
Full PICO framework
Population, intervention, comparison, and outcome laid out for every proposed topic — not just a headline.
The primary studies, named
Every topic lists the actual studies — with PMIDs — that would go into the review, so you can verify before you commit.
Nothing hidden
Topics the agent considered and ruled out, and ones it flagged as still possible, are shown alongside the one it picked.
An interactive literature map
Explore the whole corpus yourself, clustered and ranked by novelty and recency, beyond just the top suggestion.
Free to try, simple to scale
Every account starts free. Upgrade any time for more discoveries per month.
$30/mo
200 runs / month
full results
Billed $30 every month. Renews automatically until you cancel.
Get started$60 / 3 months
600 runs every 3 months
full results
Billed $60 every 3 months. Renews automatically until you cancel.
Get startedPaid plans renew automatically until you cancel. Cancel any time yourself from your account. See the Refund & Cancellation Policy.
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